Tag Archives: DNA

The Divine Anatomy of the Human Body

This week we conclude the fourth book of the Torah (Bamidbar) with the double parasha of Matot and Massei. The latter lists the 42 stops that the Israelites made during the course of their forty year sojourn in the Wilderness. While we know that this forty year period was a “punishment” because the Israelites failed to enter and settle the Holy Land as commanded, there are deeper reasons as well. One of these is that the Israelites spent those four decades learning the Torah for the first time. In some ways, it was like their gestation period.

The Sages compared the 40 years in the Wilderness to the 40 weeks of pregnancy, and pointed out that the gematria of Bamidbar (במדבר) is 248, equal to rechem (רחם), “womb”. This number is not random, for the Sages enumerated precisely 248 parts of the body, which first develop in the womb. The number agrees with modern science, the human body having 206 bones and about 42 major organs (though the latter number is subject to some controversy, depending on how one defines “organ”). The 42 stops that the Israelites made in the Wilderness neatly parallel the 42 organs. The number 206, meanwhile, is the gematria of davar (דבר), literally “word” or “thing”, and is the root of Bamidbar, “In the Wilderness”. The Wilderness was where Israel first heard the Word of God, and where Israel was officially born as a people.

So, there was something of a “divine anatomy” to the time and place of the Israelite wandering. In a similar—and far more amazing—way, there is a “divine anatomy” to the human body.

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A Mystical Look at Pregnancy and Abortion

Parashat Tazria begins by stating that a woman who gives birth to a son is spiritually impure for seven days, and requires another 33 days of purification afterwards. If she gives birth to a female, the impurity lasts fourteen days, followed by 66 days of purification. The Zohar (III, 43b) comments on this section by first reminding us that each soul has male and female halves, and when the soul enters this world, it splits and enters two different bodies, male and female. If the two soulmates merit it, they will find each other and reunite. We are then told that the female part of the soul is larger and more powerful, which is why a woman who gives birth to a female needs double the purification time.

The Zohar explains why the Torah prescribes these specific time periods: 7 and 33 days for boys; 14 and 66 days for girls. It states that at birth, the soul first enters the body and is in complete disarray. For the first seven days, the unsettled soul “roams the body to find its place”. On the eighth day, the soul is finally getting comfortable in its new home. This is one reason why circumcision is done on the eighth day, once the soul is no longer distressed. The soul then needs an additional 33 days to acclimatize to its new environment until it has completely settled into the body. For the greater female souls, the time periods are doubled.

Note how these time periods are referring to the soul of the newborn, yet it is the mother that is described as being “impure”. This is because the mother carried the child, and its soul was housed within her temporarily. (Perhaps this extra soul is responsible for the well-known “pregnancy glow”.) Once the baby is born, its soul leaves the mother’s shelter and is now independent in the baby’s body. (And that pregnancy glow is gone!) The sudden loss of spiritual energy is difficult on the mother as well, and she requires forty (or eighty) days to get back to herself.

A major question arises here: if the soul only enters the newborn at birth, why is abortion forbidden? Religious groups of various faiths have argued for centuries on when exactly the soul enters the body, and many have taken the stance that a fetus already carries a soul, making abortion indistinguishable from murder. What do Jewish texts say?

Abortion and Gestation in the Talmud

In one passage, the Talmud includes abortion under the category of murder. However, it also famously states that if the mother’s life is at risk—at any point in the pregnancy—the fetus must be removed, “limb by limb” if necessary. In such cases, the fetus is seen as a rodef, a “pursuer”, referring to the Torah law that if one is “pursuing” another to kill them, it is permitted to kill the pursuer first. The Talmud concludes that a fetus can be aborted at any point until its head has emerged. Once the head has emerged, the newborn is considered completely alive, and in cases of life-risk, it is no longer clear who the “pursuer” is. The Sages suggest that the soul fully enters the newborn only at birth, and it is only then that the newborn is a complete person.

Three-month old fetus (Courtesy: BabyCentre)

Elsewhere in the Talmud (Niddah 8b), we are told that the fetus already resembles a person at the three-month mark. We now know that it is precisely around this point that the developing baby has the features of a human (and is no longer called an “embryo”, but a “fetus”). The Talmud adds (Berakhot 60a) that until this three-month mark, a person should pray every day that there shouldn’t be a miscarriage. After three months, a person should pray that the fetus will not be stillborn, and after six months, a person should pray that the mother has an easy delivery. We are told that one should pray for the baby’s desired gender only before the 40-day mark. This, too, shows incredible wisdom on the part of our Sages. Today we know scientifically that the sex organs begin their development around day 42. The ancient rabbis knew that after day 40, gender development is already in progress, and there is no point praying for something different.

In a related passage, we are told that until day 40, the fetus is insignificant and more lifeless than living (Yevamot 69b). Today we know that the neural tube which will make the brain forms around day 40, and this is when the first neurons start signalling. Scientifically speaking, there could be no talk of any kind of consciousness or brain activity before day 40.

Because of this, most rabbinic authorities are far more lenient when it comes to abortions before the 40th day of pregnancy. Rabbi Chaim Ozer Grodzinski (1863-1940), who was widely recognized as the greatest posek of his generation, even suggested that abortions before the 40th day are not Biblically prohibited (Achiezer, III, 65:14). Nevertheless, even before the 40th day there is a potential to produce a living human being, and life is valued above all else, which is why abortions are still forbidden except for cases of absolute necessity.

By the 20-week mark (midway through pregnancy), fetuses are seen rolling around, sucking their thumbs, and responding to the prodding of the ultrasound. There is no doubt that the fetus is alive and aware at this point, and any abortion other than a life risk is hardly distinguishable from murder.

Soul Infusion

The fact that the fetus is aware by the 20-week mark (if not sooner) suggests that it does indeed have some level of soul. Yet, earlier we saw sources seemingly propose that the soul does not enter until birth. How do we reconcile these apparent contradictions?

To answer this question it is important to keep in mind that the soul is not one uniform entity. Rather, the soul is composed of multiple layers, each made up of countless sparks. The lowest level of soul is called nefesh, the basic life essence. Above that is the ruach, “spirit”, an animating force that, among other things, gives a person their drives and inclinations. Then comes the neshamah, a higher level of consciousness and the part that gives one their unique traits and qualities. Further still is the chayah, the aura that emanates from the body, followed by the loftiest level, the yechidah, which may be described as a spiritual umbilical cord between each soul and its Creator.

The Arizal taught that ever-higher levels of soul are accessed gradually over the course of one’s life. At birth, a person has only a complete nefesh. As they grow, they are infused with ruach, which becomes fully accessible at bar or bat mitzvah age. At this point one starts to tap into their neshamah, which is wholly available only at age 20. (For this reason, the Torah considers an adult one who is over 20 years of age. Only those over 20 were counted in the census and allowed to join the military. Our Sages state that although one may be judged for their crimes before age 20 here on Earth, only those sins accrued after age 20 are judged in Heaven. Meanwhile, the Midrash notes that Adam and Eve were created as 20 year olds.) The Arizal taught that most people never end up accessing their entire neshamah, and only the most refined individuals ever unlock their chayah and yechidah.

Based on this model, we see that right from conception the developing embryo is steadily infused with nefesh, the basic life force. By day 40, there is enough nefesh for the embryo to be considered alive. In fact, it is said that this is why the gematria of אם, “mother”, is 41, since a woman becomes a mother on the 41st day of pregnancy.

Once its entire nefesh has been infused, the baby is ready to be born. At birth, it begins to receive its next soul level, the ruach. A careful look at the Zohar passage with which we started reveals that this is precisely what the Zohar meant, as it explicitly mentions the ruach entering at birth, requiring forty days to fully settle in. Therefore, a developing fetus does indeed have a soul, which is why abortion is so highly discouraged—reserved only for true medical cases—and why it has been compared to murder.

Solving a Scientific Mystery

The above also answers a mystery that has been perplexing biologists for decades: what is it that drives an embryo to grow? Why do the cells multiply, and how do they know to differentiate? Each cell is exactly the same, with the exact same set of DNA, yet one clump of cells knows to form the eyes while another knows to form the liver, and so on. Scientists have still not been able to figure out how the embryo “knows” what to do. (For that matter, we can’t figure out how any cell really “knows” what to do.)

The Kabbalists have an answer: it is the steady infusion of soul that drives a mass of undifferentiated cells to do what it needs to. It is the soul that gives the instructions for how the DNA is to be transcribed and translated in each cell, and how the cells are to interact with one another. As the soul grows, so too does the body. It is therefore not surprising that around the age when most people’s bodies stop growing, their souls tend to stop “growing” as well.

This should remind us that our education does not end with formal schooling, nor does maturing stop with the end of puberty. The process of growth and refinement, both physical and spiritual, must continue throughout life. This is the key to true self-fulfillment and happiness.

The article above is an excerpt from Garments of Light. Click here to get the book.

Jacob’s Sheep: Genetics and Epigenetics in the Torah

geneticsThis week’s parasha is Vayetze, where we read of Jacob’s arrival in Charan and the details of his twenty-year sojourn there. During this time, Jacob married (twice), had a dozen children, and toiled for his cruel father-in-law Laban. Laban recognized that he had been blessed exceedingly on account of Jacob’s presence, and offered him a new wage for his labour. By this point, Jacob knew not to trust the sly Laban, and asked simply for ownership of all the speckled and spotted sheep. Since these imperfect-looking sheep were few in number, Laban readily agreed. It appears that both Laban and Jacob were well aware of the basic principles of genetics. Today, we know that sheep have 17 or so different colour alleles, and white colour is the dominant one.

For those who have forgotten high school biology: An allele is a variation of a gene. So, for example, all humans have a gene for eye colour, but have different alleles that code for the varying colours: some have alleles for blue eyes, while others have brown eyes, etc. Each person has two alleles for every gene – one from their mother, and one from their father. Certain alleles are “dominant”, while others are “recessive”. Dominant alleles are far more likely to be expressed. In humans, brown eye colour is dominant to blue eye colour, which is why some 55% of people have brown eyes, while only about 8% have blue eyes.

Basic "Punnet squares" showing the probabilities of eye colour for the children of fully brown-eyed and blue-eyed parents, and a brown-eyed parent who carries a blue allele.

Basic “Punnet squares” showing the probabilities of eye colour for the children of fully brown-eyed and blue-eyed parents, and a brown-eyed parent who carries a blue allele. (Courtesy: The University of North Carolina at Chapel Hill)

White is the dominant allele for sheep colour, so Laban assumed he was getting a terrific deal from Jacob, who was apparently ignorant of sheep genetics. In reality, Jacob knew sheep genetics quite well, and had something else up his sleeve. He only offered Laban this deal because he knew the greedy Laban would readily agree to it. So, how would Jacob outwit his father-in-law?

A Brief Introduction to Epigenetics

Jacob was evidently a far more knowledgeable geneticist than Laban, as he was aware of a concept that has only come to light in recent decades, called epigenetics. Epigenetics refers to various layers of heritability and genetic effects which are above, or outside of (hence the Greek prefix epi), the actual genetic code. In 2008, scientists defined an epigenetic trait as “stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence.” In simple terms: the chromosome that contains the genes is altered in some way without affecting the DNA sequence (the genetic code) itself. That alteration is heritable, too, and passed down from one generation to the next.

A number of epigenetic mechanisms have been discovered. The most common are methylations and acetylations, where small molecules are attached or removed from the DNA strand, causing it to coil either more tightly or less tightly. When the DNA coils more tightly, the gene is rendered inaccessible, and cannot be expressed. If uncoiled, the gene is exposed, and can be translated into the protein it codes for, thus expressing the trait.

Coiling of DNA and gene expression. (Courtesy: National Institutes of Health)

Coiling of DNA and gene expression. (Courtesy: National Institutes of Health)

While epigenetics is quite complicated, its implications are tremendous. What it means in practical terms is that even though a person has a certain gene, that gene does not necessarily have to be expressed, as it can be silenced through epigenetic mechanisms. For example, a person who has a gene that predisposes them to cancer, God forbid, could potentially have that gene suppressed, thus eliminating their increased cancer risk. (Though they don’t work in this precise fashion, epigenetic cancer drugs are now available.) This also applies to people who might be genetically predisposed to obesity, diabetes, Alzheimer’s, or theoretically, any trait at all. A person who has both brown and blue alleles does not necessarily have to have brown eyes (which is what we would expect based on principles of classical, or Mendelian, genetics). The brown eye allele can be silenced, allowing the blue allele to be expressed fully.

The same is true for Jacob’s sheep. While the alleles for speckled and spotted sheep are recessive, the dominant white allele can be suppressed, resulting in more speckled and spotted sheep. In the Torah, we read how Jacob took tree branches and stripped away some of their bark to expose the inner white layers so that their pattern resembled that of the speckled and spotted sheep. He then placed these branches in front of the white sheep that were mating, and this resulted in the white sheep producing more speckled and spotted offspring. In this way, Jacob was quickly able to multiply the number of irregular-looking sheep in the flocks, increasing his own wealth, and leaving Laban in utter surprise.

What does science have to say about this? Is it really possible for the white sheep to produce speckled and spotted offspring just by looking at speckled and spotted tree branches? Which factors actually affect epigenetics?

The Epigenetics Revolution

In northern Sweden lies a small, isolated town called Överkalix. This town kept detailed historical records, including births, illnesses, and deaths, as well as harvests and food prices. Researchers started poring over this data and noted a number of emerging patterns. Surprisingly, those who grew up in times of relative abundance tended to live shorter and sicker lives, while those who grew up in times of relative famine were healthier and lived longer! Even more shocking was that these traits passed on to their children and grandchildren. The grandsons of those who grew up in times of abundance lived roughly six years less than grandsons of those who grew up in times of famine!

The Överkalix study opened the door to much more research on the subject, and today we know that not only does food impact our epigenetics, but so does smoking, alcohol, exercise, and just about every lifestyle choice we make. Moreover, recent studies find that not only do our actions impact our epigenetics, but even our thoughts do! In 2013, scientists discovered that meditation affects epigenetic mechanisms and results in, among other things, less inflammation in the body, better stress responses, and faster mental processes.

TIME Magazine Feature on Epigenetics

TIME Magazine Feature on Epigenetics

Epigenetics has brought about a revolution in biology, and a new realization that we are not slaves to our genome. We are very much in control of how our genes operate, and seemingly every choice we make affects our health and wellbeing, as well as the health and wellbeing of our children and grandchildren, since these epigenetic patterns are heritable. This is one of the most enlightening and liberating scientific findings, putting each person in the driver’s seat of their biological fate. It should also motivate us to make healthy lifestyle choices because, even if we might not care so much about our own health, the health of our offspring is directly impacted by our choices.

The Return of Jacob’s Sheep

If meditation plays a role in how our genes are expressed, there is no reason why other mental processes cannot do the same. By visually exposing his sheep to speckled and spotted images, Jacob may very well have triggered an epigenetic change resulting in suppression of white alleles. Neurologists have long known that there is essentially no difference in brain patterns when a person is literally seeing something versus when they are simply visualizing the same thing. If mental visualizations like meditation can affect the epigenome, then why not actual visual displays? Armed with this knowledge, Jacob outwitted his father-in-law and became an exceedingly wealthy man.

Of course, one cannot deny God’s role in the process, as Jacob himself explained to his wives (Genesis 31:7-9):

…your father mocked me and changed my wages ten times, but God did not permit him to harm me. If he would say, “Speckled ones shall be your wages,” all the animals would bear speckled ones, and if he would say, “Ringed ones shall be your wages,” all the animals would bear ringed ones. Thus, God separated your father’s livestock and gave it to me…

Changing one’s epigenetics is not so simple! As with everything else, a little help from Above is always needed. Jacob put in his effort by exposing the animals to stimulating sights, and God took care of the rest.

Jacob's sheep are unique not only in their colour, but also in that the rams have extra horns.

Jacob’s sheep are unique not only in their colour, but also in that the rams have extra horns.

Interestingly, this week saw the arrival of 119 “Jacob’s sheep” to Israel. This ancient breed of sheep originated in the Middle East approximately 5000 years ago. They were extirpated from the land of Israel long ago, but thankfully some survived and were brought across North Africa to Europe and finally America. The rare speckled and spotted sheep are in the Holy Land once more, perhaps a sign of the forthcoming return of all of Jacob’s children to their ancestral home.

 

The above is an excerpt from Garments of Light: 70 Illuminating Essays on the Weekly Torah Portion and Holidays. Click here to get the book!